Gerard Karsenty Selected Research

Osteocalcin

1/2018	Osteocalcin in the brain: from embryonic development to age-related decline in cognition.
12/2017	Modulation of cognition and anxiety-like behavior by bone remodeling.
6/2017	Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
9/2014	FGF-21 and skeletal remodeling during and after lactation in C57BL/6J mice.
5/2014	Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis.
4/2014	Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.
9/2013	Maternal and offspring pools of osteocalcin influence brain development and functions.
6/2013	Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.
3/2012	T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts.
4/2011	The osteoblast: an insulin target cell controlling glucose homeostasis.

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Gerard Karsenty Research Topics

Disease

17	Bone Resorption 12/2017 - 07/2003
13	Insulin Resistance 10/2022 - 08/2007
8	Osteoporosis 01/2022 - 11/2002
6	Obesity 11/2018 - 11/2006
5	Hypertrophy 10/2021 - 11/2004
3	Neoplasms (Cancer) 01/2019 - 04/2009
3	Cognitive Dysfunction 01/2018 - 05/2016
3	Metabolic Bone Diseases (Osteopenia) 06/2017 - 05/2005
3	Glucose Intolerance 04/2014 - 08/2007
2	Infections 01/2020 - 08/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2019 - 01/2019
2	Carcinogenesis 01/2019 - 12/2004
2	Inflammation (Inflammations) 01/2019 - 01/2013
2	Hypoglycemia (Reactive Hypoglycemia) 09/2015 - 05/2014
2	Body Weight (Weight, Body) 01/2013 - 01/2004
2	Feeding and Eating Disorders (Eating Disorder) 09/2011 - 01/2011
2	MASS syndrome 03/2010 - 09/2003
2	Hypocalcemia 03/2010 - 07/2009
2	Osteoarthritis 08/2006 - 08/2005
2	Vascular Calcification 05/2006 - 10/2002
1	Type 2 Diabetes Mellitus (MODY) 01/2021
1	Overweight 01/2020
1	Morbid Obesity 01/2020
1	Osteopetrosis 01/2019
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2019
1	Non-alcoholic Fatty Liver Disease 11/2018
1	Neurobehavioral Manifestations 12/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017
1	Neuroinflammatory Diseases 05/2016
1	Alzheimer Disease (Alzheimer's Disease) 05/2016
1	Hyperglycemia 05/2014
1	Tuberous Sclerosis 2 05/2014
1	Memory Disorders (Memory Loss) 09/2013
1	Hypoxia (Hypoxemia) 06/2013
1	Asthma (Bronchial Asthma) 01/2013
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2012
1	Starvation 03/2012
1	Hyperphosphatemia 03/2010
1	Multiple Myeloma 04/2009
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2009
1	Hematologic Neoplasms (Hematological Malignancy) 04/2009
1	Multiple Sulfatase Deficiency Disease (Mucosulfatidosis) 02/2009
1	Hyperinsulinism (Hyperinsulinemia) 12/2008

Drug/Important Bio-Agent (IBA)

15	OsteocalcinIBA 01/2018 - 08/2007
12	Glucose (Dextrose)FDA LinkGeneric 10/2022 - 01/2004
10	LeptinIBA 01/2022 - 11/2002
9	Serotonin (5 Hydroxytryptamine)IBA 01/2019 - 03/2010
7	Insulin (Novolin)FDA Link 09/2015 - 07/2010
4	Proteins (Proteins, Gene)FDA Link 10/2021 - 07/2003
4	Hormones (Hormone)IBA 01/2018 - 11/2006
4	RANK LigandIBA 03/2013 - 07/2003
4	Transcription Factors (Transcription Factor)IBA 08/2006 - 11/2004
3	Phosphotransferases (Kinase)IBA 10/2021 - 12/2006
3	Messenger RNA (mRNA)IBA 09/2014 - 01/2004
3	Insulin ReceptorIBA 05/2014 - 03/2012
2	ClenbuterolIBA 10/2022 - 10/2021
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2016 - 05/2016
2	Peptide Hydrolases (Proteases)FDA Link 04/2013 - 07/2003
2	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2013 - 03/2010
2	Amino Acids FDA Link 03/2012 - 12/2006
2	Parathyroid Hormone-Related ProteinIBA 03/2010 - 04/2006
2	CalciumIBA 03/2010 - 05/2006
2	Amphetamine (Amfetamine)FDA LinkGeneric 07/2006 - 03/2005
2	Cocaine (Cocaine HCl)IBA 07/2006 - 03/2005
2	Matrix Gla ProteinIBA 05/2006 - 10/2002
2	beta CateninIBA 04/2006 - 05/2005
2	OsteopontinIBA 12/2004 - 10/2002
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2021
1	PyrophosphatasesIBA 01/2021
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2020
1	Interleukin-33IBA 01/2020
1	Neuroprotective AgentsIBA 02/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2019
1	Pharmaceutical PreparationsIBA 11/2018
1	Interleukin-12 (IL 12)IBA 01/2017
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 01/2017
1	ectonucleotide pyrophosphatase phosphodiesterase 1IBA 12/2014
1	diphosphoric acid (pyrophosphoric acid)IBA 12/2014
1	fibroblast growth factor 21IBA 09/2014
1	Staphylococcal Protein A (Protein A)IBA 05/2014
1	Fatty Acids (Saturated Fatty Acids)IBA 04/2014
1	Testosterone (Sustanon)FDA Link 06/2013
1	GTP Phosphohydrolases (GTPases)IBA 03/2012
1	Mechanistic Target of Rapamycin Complex 1IBA 03/2012
1	Non-Receptor Type 2 Protein Tyrosine PhosphataseIBA 03/2012
1	Neurotransmitter Agents (Neurotransmitter)IBA 10/2010
1	MineralsIBA 03/2010
1	AdiponectinIBA 10/2009
1	Parathyroid Hormone (Parathormone)IBA 07/2009
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/2009
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 04/2009
1	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 04/2009
1	GlycosaminoglycansIBA 02/2009
1	SulfatasesIBA 02/2009

Therapy/Procedure

1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2019
1	Therapeutics 01/2017
1	Immunotherapy 01/2017
1	Ovariectomy (Oophorectomy) 09/2011
1	Oral Administration 03/2010